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Possible additional value of 18FDG-PET in managing pancreas intraductal papillary mucinous neoplasms: Preliminary results

By Gian Luca Baiocchi, Nazario Portolani, Francesco Bertagna, Federico Gheza, Claudio Pizzocaro, Raffaele Giubbini and Stefano M Giulini


Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patients with Intraductal Papillary Mucinous Neoplasm (IPMN) studied both with 18FDG-PET and magnetic resonance cholangiopancreatography (MRCP). A focal hypermetabolism was documented in 2 patients (the standardized uptake value in the neoplastic foci was 6.7 and 9), while absence of FDG uptake in the neoplasm area was recorded in the remaining 5 cases. Mean follow-up was 27 months (range 21–34). The final judgement was benign IPMN in 5 cases and malignant IPMN in 2. PET scan always correctly predicted the presence or absence of malignancy, while MRCP failed to detect malignancy in 3/7 cases. In conclusion, this preliminary experience suggests that 18FDG-PET may prove useful for malignancy detection in IPMN, improving differential diagnosis with benign intraductal papillary growth by functional data

Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1998). Atomi Y: Intraductal papillary mucinous tumors of the pancreas: imaging studies and treatment strategies. Ann Surg
  2. (2001). Clinicopathological features and treatment of intraductalpapillary mucinous tumours of the pancreas.
  3. Cystic tumours of the pancreas.
  4. (2000). FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features.
  5. (2006). International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology
  6. Intraductal-papillary mucinous neoplasms of the pancreas. In World Health Organization classification of tumors. Pathology and genetics of tumors of the digestive system Edited by: Hamilton SR,
  7. (2004). Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg
  8. (1999). MW: Diagnosis and staging of pancreatic cancer by positron emission tomography. World J Surg
  9. (2005). Pedrazzoli S: F-18-fluorodeoxyglucose positron emission tomography in differentiating malignant from benign pancreatic cysts: a prospective study.
  10. (2003). Positron emission tomography with 2-deoxy-2-[(18)F] fluoro-d-glucose for diagnosis of intraductal papillary mucinous tumor of the pancreas with parenchymal invasion.
  11. (2002). Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut
  12. (2006). The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas.

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