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Small Intestine CD4+ T Cells Are Profoundly Depleted during Acute Simian-Human Immunodeficiency Virus Infection, Regardless of Viral Pathogenicity▿

By Yoshinori Fukazawa, Ariko Miyake, Kentaro Ibuki, Katsuhisa Inaba, Naoki Saito, Makiko Motohara, Reii Horiuchi, Ai Himeno, Kenta Matsuda, Megumi Matsuyama, Hidemi Takahashi, Masanori Hayami, Tatsuhiko Igarashi and Tomoyuki Miura

Abstract

To analyze the relationship between acute virus-induced injury and the subsequent disease phenotype, we compared the virus replication and CD4+ T-cell profiles for monkeys infected with isogenic highly pathogenic (KS661) and moderately pathogenic (#64) simian-human immunodeficiency viruses (SHIVs). Intrarectal infusion of SHIV-KS661 resulted in rapid, systemic, and massive virus replication, while SHIV-#64 replicated more slowly and reached lower titers. Whereas KS661 systemically depleted CD4+ T cells, #64 caused significant CD4+ T-cell depletion only in the small intestine. We conclude that SHIV, regardless of pathogenicity, can cause injury to the small intestine and leads to CD4+ T-cell depletion in infected animals during acute infection

Topics: Pathogenesis and Immunity
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2395167
Provided by: PubMed Central
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