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Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide

By T Kanzawa, I M Germano, Y Kondo, H Ito, S Kyo and S Kondo
Topics: Experimental Therapeutics
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2394478
Provided by: PubMed Central
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    1. (1999). 6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O 6-alkylguanine-DNA alkyltransferase activity.
    2. (1993). Depletion of O 6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
    3. (2003). Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.
    4. (1990). sthe antitumor drug temozolomide and its interaction with DNA.
    5. (1997). Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955–959

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