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Facile whole mitochondrial genome resequencing from nipple aspirate fluid using MitoChip v2.0

By John P Jakupciak, Andrea Maggrah, Samantha Maragh, Jennifer Maki, Brian Reguly, Katrina Maki, Roy Wittock, Kerry Robinson, Paul D Wagner, Robert E Thayer, Ken Gehman, Teresa Gehman, Sudhir Srivastava, Alioune Ngom, Gabriel D Dakubo and Ryan L Parr
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2006). AJ: Presence of epithelial cells in nipple aspirate fluid is associated with subsequent breast cancer: a 25-year prospective study. Breast Cancer Res Treat
  2. (2006). Analysis of potential cancer biomarkers in mitochondrial DNA. Current Opinion in Molecular Therapeutics
  3. (2001). B r e a s t c a n c e r r i s k i n w o m e n w i t h a b n o r m a l cytology in nipple aspirates of breast fluid.
  4. (1993). Breast cancer risk associated with abnormal cytology in nipple aspirates of breast fluid and prior history of breast biopsy.
  5. (2007). Califano JA: Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
  6. (2004). Chakravarti A: The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res
  7. (2007). Chang HR: Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry.
  8. (2004). CJ: Failure of high risk women to produce nipple aspirate fluid does not exclude detection of cytologic atypia in random periareolar fine needle aspiration specimens. Breast Cancer Res Treat
  9. (2006). De Coo IF, Briem E, Tiranti V, Smeets HJ: Chip-based mtDNA mutation screening enables fast and reliable genetic diagnosis of OXPHOS patients. Genet Med
  10. (2001). Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res
  11. (2004). Ductal lavage findings in women with known breast cancer undergoing mastectomy.
  12. (2001). EB: Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.
  13. (2001). Eeles RA: Cellular characteristics of nipple aspiration fluid during the menstrual cycle in healthy premenopausal women. Cytopathology
  14. (2004). Haddad BR: Detection of LOH and mitochondrial DNA alterations in ductal lavage and nipple aspirate fluids from hnghrisk patients. Breast Cancer Res Treat
  15. (1990). Hauck WW: Factors associated with obtaining nipple aspirate fluid: analysis of 1428 women and literature review. Breast Cancer Res Treat
  16. (2006). HC: Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer
  17. (2007). Helzlsouer KJ: The reliability of nipple aspirate and ductal lavage in women at increased risk for breast cancer--a potential tool for breast cancer risk assessment and biomarker evaluation. Cancer Epidemiol Biomarkers Prev
  18. (2005). King BL: Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer. Breast Cancer Res
  19. (2007). Klein-Szanto A: Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Detect Prev
  20. (2003). Kuerer HM: Nipple aspirate fluid cytology in breast carcinoma. Cancer
  21. (2006). Love SM: The intraductal approach to the breast: raison d'etre. Breast Cancer Res
  22. (2008). Mitochondrial genome analysis in biofluids for early cancer detection and monitoring. Expert Opin Med Diagn
  23. (2000). Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res
  24. (2005). O'Connell C D: Mitochondrial DNA as a cancer biomarker. J Mol Diagn
  25. (2004). Organization and dynamics of human mitochondrial DNA.
  26. (2008). Parr RL: Mitochondrial genome deletion aids in the identification of false- and true-negative prostate needle core biopsy specimens.
  27. PHYLIP - Phylogeny Inference Package (Version
  28. (2005). Sauter ER: Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid. Carcinogenesis
  29. (2000). Sidransky D: Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science
  30. (2001). Sidransky D: Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene
  31. (2007). Smeets H: mtDNA point mutations are present at various levels of heteroplasmy in human oocytes. Mol Hum Reprod
  32. (1998). Vogelstein B: Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet
  33. (2001). WC: Mitochondrial DNA in human malignancy. Mutat Res