Article thumbnail

High risk mammographic parenchymal patterns and diet: a case–control study

By E Sala, R Warren, S Duffy, A Welch, R Luben and N Day

Abstract

Mammographic parenchymal patterns are related to breast cancer risk and are also thought to be affected by diet. We designed a case–control study comprising 200 cases with high-risk (P2 and DY) mammographic parenchymal pattern and 200 controls with low-risk (N1 and P1) patterns in order to investigate the effect of food and nutrient intake on mammographic patterns. Mammograms were evaluated according to the Wolfe classification system. Dietary data were obtained from 7-day food diaries. Mean daily intake of nutrients was computed from standard UK food tables. The adjusted odds ratio (OR) of having a high-risk pattern in women in the highest tertile of total protein and carbohydrate intake was twice that of women in the lowest tertile (OR = 2.00; 95% confidence interval (CI) 1.06–3.77;P = 0.04 and OR = 1.93; 95% CI 1.03–3.59;P = 0.04 respectively). There was no excess risk for fat intake. In addition, there was no association between intake of vitamins and mammographic parenchymal patterns. Total meat intake was strongly and positively associated with high-risk patterns among post-menopausal women (OR = 2.50, 95% CI 1.09–5.69, P = 0.03). Our study suggests that certain macronutrients and foods such as protein, carbohydrate and meat intake influence the risk of breast cancer through their effects on breast tissue morphology, whereas fat and vitamins do not affect mammographic density. It seems that parenchymal pattern acts as an informative biomarker of the effect of some macronutrient and foodstuffs intake on breast cancer risk. © 2000 Cancer Research Campaig

Topics: Regular Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2374534
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1993). A meta-analysis of studies of dietary fat and breast cancer risk.
  2. (1996). Cohort studies of fat intake and risk of breast cancer – a pooled analysis.
  3. (1981). Diet and reproductive hormones: a study of vegetarian and non-vegetarian postmenopausal women.
  4. (1989). Diet, mammographic features of breast tissue, and breast cancer risk. Am J Epidemiol 130: 14–24 Clavel Chapelon
  5. (1992). Dietary fat and fibre in relation to risk of breast cancer. An 8-year follow-up.