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Evaluation of the energetic contribution of an ionic network to beta-sheet stability

By Kirsten S. Lassila, Deepshikha Datta and Stephen L. Mayo


We have evaluated the interaction energy of a three-residue ionic network constructed on the β-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by ∼0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol)

Topics: For the Record
Publisher: Cold Spring Harbor Laboratory Press
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Provided by: PubMed Central
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