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An ordered subset approach to including covariates in the transmission disequilibrium test

By Hervé Perdry, Brion S Maher, Marie-Claude Babron, Toby McHenry, Françoise Clerget-Darpoux and Mary L Marazita


Clinical heterogeneity of a disease may reflect an underlying genetic heterogeneity, which may hinder the detection of trait loci. Consequently, many statistical methods have been developed that allow for the detection of linkage and/or association signals in the presence of heterogeneity

Topics: Proceedings
Publisher: BioMed Central
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Provided by: PubMed Central

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