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Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

By Anupa Murugkar, Bindu Unnikrishnan, Subhash Padhye, Ramesh Bhonde, Simon Teat, Evangelia Triantafillou and Ekkehard Sinn


Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl1] followed by [Cu(TATSC)Cl2] and the ligand in compariosn with cisplatin

Topics: Research Article
Publisher: Hindawi Publishing Corporation
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Provided by: PubMed Central

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