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Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

By Anupa Murugkar, Bindu Unnikrishnan, Subhash Padhye, Ramesh Bhonde, Simon Teat, Evangelia Triantafillou and Ekkehard Sinn

Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl1] followed by [Cu(TATSC)Cl2] and the ligand in compariosn with cisplatin

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:2366831
Provided by: PubMed Central

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Citations

  1. (1994). (b) P.Sonawane, A.Kumbhar, S.Padhye and R.J.Butcher,
  2. (1997). A New High Flux Chemical and Materials Crystallography Station at the SRS Daresbury Part 1. Design, Commissioning and Test Results- R.J.Cernik, W.Clegg,
  3. (1984). an integrated direct methods computer program (incorporates MULTAN),
  4. (1985). Analysis Package, Molecular Structure Corporation
  5. (1997). Angerer," The Estrogen Receptor as a target for Rational Drug Design",
  6. (1980). Breast CancerExperimental and Clinical Aspects",
  7. International Tables for X-ray Crystallography,", Vol.
  8. (1993). Oshawa and R.M.Hoffman,
  9. (1996). Received"
  10. (1992). S.J.Shallon and M.P.Chitnis,