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Pathogenesis of Machupo virus infection in primates*

By G. A. Eddy, S. K. Scott, F. S. Wagner and O. M. Brand


Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys

Topics: Session II—Pathology and Pathogenesis
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Provided by: PubMed Central
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