Location of Repository

Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO5: At Least Three Independent Reaction Pathways

By Andrea Lapi, Geneviève Pratviel and Bernard Meunier

Abstract

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO5 on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:2365246
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (1999). Acad Sci.
    2. (1994). Environmental Health Perspectives
    3. Imidazolone nucleoside derivative (dlz) corresponds to 2-mnino-5-[(2-deoxy-fl -D-e.thropentofumnosyl)amino]-4H-imidazol-4-one and oxazolone nucleoside derivative (dZ) to 2,2-diamino-4-[2-deoxy--D-erythropentofuranosyl)amino]-2,5-dihydrooxazol-5-one.
    4. (1987). The Chemical Basis ofRadiation Biology;

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.