Location of Repository

Carbonic Anhydrase Inhibitors. Part 551 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV

By Claudiu T. Supuran, Andrea Scozzafava, Fabrizio Briganti, Marc A. Ilies and Andrei Jitianu

Abstract

Coordination compounds of 5-chloroacetamido-1,3,4-thiadiazole-2-sulfonamide (Hcaz) with V(IV), Cr(lll), Fe(ll), Co(ll), Ni(ll) and Cu(ll) have been prepared and characterized by standard procedures (spectroscopic, magnetic, EPR, thermogravimetric and conductimetric measurements). Some of these compounds showed very good in vitro inhibitory properties against three physiologically relevant carbonic anhydrase (CA)isozymes, i.e., CA I, II, and IV. The differences between these isozymes in susceptibility to inhibition by these metal complexes is discussed in relationship to the characteristic features of their active sites, and is rationalized in terms useful for developing isozyme-specific CA inhibitors

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:2365105
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (1993). 1, 77-116; b) C.T. Supuran, "Carbonic anhydrase inhibitors",
    2. (1995). 2, 327-330; b) C.T. Supuran, Metal Based Drugs,
    3. (1982). Benzolamide", in "Orphan Drugs",
    4. (1987). Copper", in "Comprehensive Coordination Chemistry",
    5. (1998). Enzyme Inhib.,
    6. (1983). Exp.Eye Res.,
    7. (1996). Farmacologia clinica da ulcera peptica" in "Aparelho Digestivo",
    8. (1991). in "Carbonic anhydrase From Biochemistry and Genetics to Physiology and Clinical
    9. (1991). in "Carbonic anhydrase- From Biochemistry and Genetics to Physiology and Clinical
    10. (1977). in "Physical Methods in Chemistry",
    11. Inhibition of carbonic anhydrase ", in "Design of Enzyme Inhibitors as Drugs",
    12. (1984). Inorganic Electronic Spectroscopy", 2 d Edition,
    13. (1989). Jaanus "Carbonic anhydrase inhibitors". In "Clinical Ocular Pharmacology", Second Editien, Butterworths Publishers,
    14. (1997). Metal Based Drugs,
    15. (1987). Nickel", in "Comprehensive Coordination Chemistry",
    16. (1997). Preceding part of this series:
    17. (1997). Received in revised camera-ready format"

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.