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The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system

By A S Y W Burns, E Jaros, M Cole, R Perry, A J Pearson and J Lunec

Abstract

One hundred and one pre-treatment primary central primitive neuroectodermal tumours were analysed for the expression of p53 protein by immunohistochemistry using the monoclonal antibody DO-7. The staining intensity was classified into four groups: strong, medium, weak and negative and strong staining intensity was associated with the poorest survival. DNA sequencing of the p53 gene was performed in 28 cases representing all four staining groups. Mutations were found in only three of the strong staining tumours suggesting that DNA mutations were not common events and that in the majority of the tumours with over-expressed p53, the protein was likely to be wild-type. Results of immunohistochemistry showed a significantly positive relationship between the expression of p53 and Bax and Bcl-2 proteins, but not Waf-1. Multivariate analyses supported the prognostic value of p53 immunostaining in central primitive neuroectodermal tumours and also of age and gender of patients

Topics: Molecular and Cellular Pathology
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2364191
Provided by: PubMed Central
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    1. (1994). p53 gene mutation and Mdm2 gene ampliļ¬cation are uncommon in medulloblastoma.
    2. (1993). WAF1 a potential mediator of p53 tumor suppression.

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