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Role of survivin and its splice variants in tumorigenesis

By F Li

Abstract

Survivin, a unique member of the inhibitor of apoptosis (IAP) protein family, is highly expressed in cancer but is undetectable in nonproliferating normal adult tissues, suggesting a potential role in tumorigenesis. Differential splicing of survivin pre-mRNA results in three new survivin variants, survivin-ΔEx3, survivin-2B, and survivin-3B. Loss of survivin-2B expression was found in the later stage of cancer development, while survivin and survivin-ΔEx3 are not, suggesting a differential role of them in tumour development. In this minireview, the author intends to summarise and discuss the current data relevant to the role of survivin and its splicing variants in tumorigenesis, which may facilitate further investigation in this interesting area

Topics: Reviews
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2361850
Provided by: PubMed Central
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    1. (2003). HBXIP functions as a cofactor of survivin in apoptosis suppression.
    2. (2003). Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.

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