Background and aims: Several studies showed a protective effect of\ud moderate alcohol intake on cardiovascular risk. We investigated the effects\ud of moderate alcohol intake on inflammatory and haemostatic parameters in\ud 17 healthy women (age 53±5years) with ≥2 vascular risk factors for CVD.\ud Study protocol: 3-week run-in phase with isoenergetic non antiinflammatory\ud ethanol free diet (T0-T21); 3-week isoenergetic diet and\ud white wine (20g alcohol equivalent/die) (T21-T42); 3-weeks on the same\ud diet with the addition of 3 portions/week of fish and nuts, low glycemic\ud index carbohydrates, and soluble fibres (“anti-inflammatory” diet) (T42-\ud T63); 3-weeks on the run-in phase diet (T63-T84). At baseline and at\ud the end of each period anthropometric index, fat mass, lipid profile, CRP,\ud IL-6, TNF-alpha, fibrinogen, vonWillebrand factor (vWf:Ag), tissue factor\ud (TF:Ag), factor VII (FVII:Ag and c), factor VIII (FVIII:Ag) and thrombin\ud generation parameters in plasma were measured.\ud Results: Over the study period BMI, fat mass, triglycerides, LDL and\ud HDL-cholesterol did not significantly change compared to baseline levels,\ud whereas a reduction in total cholesterol levels was observed (p<0.05).\ud Among inflammatory parameters, only IL-6 levels showed a reduction\ud (p=0.09), non statistically significant. Alcohol intake, on the other hand,\ud was associated with TF:Ag (p<0.05) and FVII:Ag (p<0.05) reduction.\ud These results were paralleled by an increase of thrombin generation Lag\ud Time (p<0.002) and ttPeak (p< 0.02).\ud Conclusions: In middle-aged women, moderate alcohol intake reduced\ud plasma levels of factors triggering blood coagulation and prolonged the\ud initiation phase of thrombin generation. These information support a\ud protective vascular effect of alcohol intake at the tested doses
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