oaioai:CiteSeerX.psu:10.1.1.1025.8062

Pulmonary function in primary pulmonary hypertension

Abstract

OBJECTIVES The study was done to ascertain the degree to which abnormalities in resting lung function correlate with the disease severity of patients with primary pulmonary hypertension (PPH). BACKGROUND Patients with PPH are often difficult to diagnose until several years after the onset of symptoms. Despite the seriousness of the disorder, the diagnosis of PPH is often delayed because it is unsuspected and requires invasive measurements. Although PPH often causes abnormalities in resting lung function, these abnormalities have not been shown to be statistically significant when correlated with other measures of PPH severity. METHODS Resting lung mechanics and diffusing capacity for carbon monoxide DLCO were assessed in 79 patients whose findings conformed to the classical diagnostic criteria of PPH and who had no evidence of secondary causes of pulmonary hypertension. These findings were correlated with severity of disease as assessed by cardiac catheterization, New York Heart Association (NYHA) class, and cardiopulmonary exercise testing. RESULTS When PPH patients were first evaluated at our referral clinic, the DLCO and lung volumes were decreased in approximately three-quarters and one-half, respectively. The decreases in DLCO, and to a lesser extent lung volumes, correlated significantly with decreases in peak oxygen uptak

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oaioai:CiteSeerX.psu:10.1.1.1025.8062Last time updated on 4/12/2017

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