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REVIEW Quality of Life, Fertility Concerns, and Behavioral Health Outcomes in Younger Breast Cancer Survivors: A Systematic Review

By Jessica Howard-anderson, Patricia A. Ganz, Julienne E. Bower and Annette L. Stanton


Breast cancer is the most common cancer in women, and for those younger than 50 years of age, it is the leading cause of death in the United States (1). However, the survival rate for these younger women with breast cancer has improved continuously over the past two decades, primarily because of the widespread introduction of adjuvant chemotherapy and endocrine therapies (2). Today many younger women can expect long-term survival; however, the quality of their lives may be hampered by premature menopause, infertility, negative psychosocial effects, and risk for recurrence and second episodes of primary breast cancer (3–8). From the per-spective of cancer control, younger breast cancer survivors are an important target population for interventions that focus on phys-ical and psychological symptom relief, cancer prevention, and risk reduction. To identify potential opportunities for cancer prevention and control interventions in this population, we undertook a systematic review of the literature focused on potentially mutable outcomes. We were particularly interested in the impact of breast cancer on health-related quality of life (QOL) (ie, physical functioning and emotional well-being, depression, and anxiety), unique psychoso-cial difficulties related to treatment-associated reproductive changes (ie, onset of menopause and its symptoms, concerns abou

Year: 2016
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