Potential Iatrogenic Alteration to 18F-Fluoride


genuine clinical alternative to 99mTc-diphosphonate scintigraphy. In vivo, NaF dissociates into its salts Na1 and F2 (fluoride). Fluoride is exchanged with OH2 (hydroxyl) ion in the hydroxy-apatite matrix of the bone before migrating into the crystalline matrix (1). Approximately 50 % of the injected dose localizes in bone, and bone retention of fluoride continues until bone re-modeling (1). Fluoride has minimal protein binding affinity, allowing more rapid excretion of the fraction not localized in bone and favoring earlier postadministration imaging and low background activity (1). Elevation in plasma concentrations of unlabeled fluoride may reduce 18F-fluoride uptake because of competition. In vivo competition is likely to increase the ratio of 18F-fluoride excreted to 18F-fluoride bound in bone, decreasing the percentage of the injected dose localizing in the bone. The effects on image quality may include a decrease in target orga

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