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Copyright ©D 1991, American Society for Microbiology T-Cell Proliferative Response to Antigens Secreted by

By Mycobacterium Tuberculosis


An infection model of human tuberculosis was established with C57BL/6J mice. The lymphocyte proliferative responses to antigens from Mycobacterium tuberculosis were investigated during the course of infection and compared with results obtained with a group of mice immunized with large amounts of killed bacteria. The two groups responded similarly to a number of mycobacterial antigens, but marked differences in responses against secreted antigens were found; only infected mice responded vigorously to these. The responding lymphocyte subpopulation was made up of L3T4+ T lymphocytes under restriction of the Ia molecule. It is established that resistance to infection with Mycobac-terium tuberculosis is efficiently evoked only by the living organism (8, 17, 24). Killed bacteria are able to activate the immune system but are not able to evoke a long-term specific cellular immunity (24, 25). Furthermore, major differences in the T-lymphocyte repertoire stimulated by live and dead mycobacteria have been reported (27). On the basis of these results, a possible role in protection for proteins secreted from the actively replicating mycobacteria has been sug

Year: 1990
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