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N: Developmental hemodynamic changes in the chick embryo from stage 18 to 27. Circ Res

By Edward B. Clark and Norman Hu


(from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic diameter and embryo weight of each developmental stage. From these data, we calculate mean dorsal aortic blood flow, mean dorsal aortic blood flow per cardiac cycle, mean dorsal aortic blood flow per milligram embryo weight, vascular resistance and cardiac work. Blood flow increases geometrically with each embryo stage but remains constant when normalized for embryo weight. Mean arterial pressure increases linearly and vascular resistance decreases geometrically. Cardiac work increases in proportion to embryo weight. These results define the parameters of normal hemodynamic function during early embryonic development. (Ore Res 51: 810-815, 1982) BLOOD FLOW in the embryo begins soon after the tubular heart starts to pulsate and continues during subsequent morphogenesis of the cardiovascular sys-tem. Since form and function are interrelated, it is important to understand the contribution of each i

Year: 2016
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