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By James Walker


given an excellent review of the past investigations of the properties of the different hemoglobins in the blood of adult and fetal mammals9 He has added much by his paper to his already substantial con-tribution to the subject. I am grateful in such a gathering to present a summary of our recent find-ings in a study of the two hemoglobins in the blood of the human fetus from the tenth to the 43rd week of pregnancy. Figure 1 demonstrates results obtained by Dr. Elizabeth Turnbull and myself in our investigation of the percentage of adult hemoglobin in the blood of the human fetus in 131 cases9 Dr. Turnbull used an alkali denaturation method (originally described by Brinkman and Jonxis, 1937, modified by Jonxis, 1952) 9 We found that adult hemoglobin could first be detected at the 13th week (menstrual age) when it formed one to two per cent of the total hemoglobin, which at that time is about 10 g per cent. By the 22nd to 24th weeks it had reached 10 per cent of the total hemoglobin. The adult hemoglobin ap-pears to remain at or about hat level till about he 35th week at which time the readings begin to spread until at the 40th week the levels range from 11 to 39 per cent with a mean of 22.2 per cent. In the 41st and 42nd weeks the mean value was 30.7 per cent. In the cord blood of the fetus at birth at or near term a somewhat similar r nge of adult hemoglobin percentage has been found by Jonxis (1949) and Schulman (1953) amongst others9 I have sought an explanation of the scatter in readings after the 35th week and also at the same time studied the response to anoxia in constitutio

Year: 2016
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