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Finer Snapshot of Circulating Mycobacterium tuberculosis Genotypes in

By Julie Millet, William Laurent, Thierry Zozio and Nalin Rastogi


This study shows the benefit of spoligotyping coupled to mycobacterial interspersed repetitive-unit (MIRU) typing to pinpoint circulating Mycobacterium tuberculosis genotypes in Guadeloupe, Martinique, and French Guiana. We hereby propose reduced 4-locus and 6-locus subsets for LAM and Haarlem lineage strains that predominate in South America and the Caribbean, retaining 99.35 % and 99.64 % of the total discriminatory power of the 12-locus scheme, respectively. The present investigation provides an improved phyloge-netic characterization of existing Mycobacterium tuberculosis transmission chains in Guadeloupe, Martinique, and French Guiana. It also aimed to estimate the benefit of 12-locus my-cobacterial interspersed repetitive-unit (MIRU) typing cou-pled to spoligotyping and to select a reduced MIRU locus typing scheme for an efficient subtyping of clusters belonging to LAM and Haarlem lineages that predominate in South America and the Caribbean (1, 3–5, 13). Under a longitudinal universal genotyping program coverin

Year: 2011
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