Article thumbnail

Finer Snapshot of Circulating Mycobacterium tuberculosis Genotypes in

By Julie Millet, William Laurent, Thierry Zozio and Nalin Rastogi

Abstract

This study shows the benefit of spoligotyping coupled to mycobacterial interspersed repetitive-unit (MIRU) typing to pinpoint circulating Mycobacterium tuberculosis genotypes in Guadeloupe, Martinique, and French Guiana. We hereby propose reduced 4-locus and 6-locus subsets for LAM and Haarlem lineage strains that predominate in South America and the Caribbean, retaining 99.35 % and 99.64 % of the total discriminatory power of the 12-locus scheme, respectively. The present investigation provides an improved phyloge-netic characterization of existing Mycobacterium tuberculosis transmission chains in Guadeloupe, Martinique, and French Guiana. It also aimed to estimate the benefit of 12-locus my-cobacterial interspersed repetitive-unit (MIRU) typing cou-pled to spoligotyping and to select a reduced MIRU locus typing scheme for an efficient subtyping of clusters belonging to LAM and Haarlem lineages that predominate in South America and the Caribbean (1, 3–5, 13). Under a longitudinal universal genotyping program coverin

Year: 2011
OAI identifier: oai:CiteSeerX.psu:10.1.1.1015.5791
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://jcm.asm.org/content/49/... (external link)
  • http://jcm.asm.org/content/49/... (external link)
  • http://citeseerx.ist.psu.edu/v... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.