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Cellular Mechanisms Involved in Protection and Recovery from Influenza Virus Infection in Immunodeficient Mice

By Wayne M. Yokoyama and Constantin A. Bona


We investigated the role of different lymphocyte subpopulations in the host defense reaction against influ-enza virus infection, taking advantage of various immunodeficient mouse strains. Whereas, following immu-nization, wild-type animals showed complete protection against challenge with a lethal dose of A/PR8/34 (PR8) virus, mice that lack both B and T cells but not NK cells (namely, scid and RAG22/2 mice) did not display any protective effect in similar conditions. By contrast, JHD 2/2 mice devoid of B cells and immunized with virus showed a protective response after challenge with a lethal dose. The immunized JHD 2/2 mice that survived completely recovered from the influenza virus infection. Immunized JHD 2/1 mice exhibited a more complete protection, suggesting the role of specific antibodies in resistance to infection. To assess the role of natural immunity in the host defense against influenza virus, we carried out experiments with scidmice challenged with lower but still lethal doses of PR8 virus. While an increased NK activity and an increased number of NK1.11 cells in lungs of scidmice infected with PR8 virus were noted, in vivo depletion of the NK1.11 cells did not affect the overall survival of the mice. Our results show that specific T cells mediate protection and recovery o

Year: 1996
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