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Translational Nephrology Control of sympathetic activity—new insights;

By Eberhard Ritz and Lars Christian Rump


induced hypertension in humans and mice. J Clin Invest 2009; 119: 3597–3612. Recently, a large international group of 25 investigators identified a candidate gene for hypertension which codes for phosducin (Pdc) as a novel player in the sympathetic nervous system [1]. In their study, a wide spectrum of find-ings documented its so-far unrecognized and apparently important role in experimental and human stress-induced hypertension. This conclusion is based on data ranging from detailed analyses of the sympathetic system in genet-ically manipulated Pdc −/ − (knock-out) mice to the dem-onstration of its relevance in humans: in two separate cohorts, French Canadian and Afro-American individuals, respectively, a correlation was documented between single-nucleotide polymorphisms (SNPs) in the Pdc gene and stress-dependent blood pressure reactions

Year: 2010
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