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Effect of Transmission Reduction by Insecticide-Treated Bednets (ITNs) on Antimalarial Drug Resistance in Western Kenya

By Monica Shah, Simon Kariuki, Jodi V, En Eng, Anna J. Blackstock, Kimberly Garner, John E. Gimnig, Kim Lindblade, Dianne Terlouw, Feiko Ter Kuile, William A. Hawley, Penelope Phillips-howard, Bernard Nahlen, Edward Walker, Mary J. Hamel, Laurence Slutsker and Ping Shi


Despite the clear public health benefit of insecticide-treated bednets (ITNs), the impact of malaria transmission-reduction by vector control on the spread of drug resistance is not well understood. In the present study, the effect of sustained transmission reduction by ITNs on the prevalence of Plasmodium falciparum gene mutations associated with resistance to the antimalarial drugs sulfadoxine-pyrimethamine (SP) and chloroquine (CQ) in children under the age of five years was investigated during an ITN trial in Asembo area, western Kenya. During the ITN trial, the national first line antimalarial treatment changed from CQ to SP. Smear-positive samples collected from cross sectional surveys prior to ITN introduction (baseline, n = 250) and five years post-ITN intervention (year 5 survey, n = 242) were genotyped for single nucleotid

Year: 2016
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