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A.: Intramyocardial pressure and strength of left veiltricular contraction. Circulation Research 10: 608

By F. Salisbury, Ph. D, Cecil E. Cross and P. Andre Rieben


• Earlier experiments 1>2 suggested that the contractile strength of the cardiac ventricles might be determined by the pressure in the coronaiy arteries and not by the quantity of metabolites supplied to the heart muscle or by presystolic factors. In further investiga-tions (reported here in section II), we con-firmed this hypothesis: coronary perfusion pressure influenced ventricular contractile strength even under conditions which ex-cluded variation of metabolic support. Coro-nary pressure might have exerted its inotropic effect, either directly, or else through a corre-sponding change of intramyocardial pressure. Since the literature did not contain informa-tion concerning factors which control intra-myocardial pressure, it was necessary to in-vestigate this entity. Data which identify determinants of intramyocardial pressure are reported here in section I; the} were a pre-requisite for further experimental analysis of factors Avhich influence contractile strength. Each parameter which had influenced intra-myocardial pressure was examined with a view to uncovering its role, if any, in the regulation of contractile strength. The data presented here indicate that: (1) all factors which are known to regulate the contractile strength of isolated hearts (dias-tolic volume, diastolic pressure, outflow re-sistance, coronary pressure, heart rate) also have the ability to cause variations of pressure within the heart muscle; (2) it is this varia-tion of "intramyocardial pressure " which brings about changes of contractile strength; and (3) the intrinsic factors which regulat

Year: 1962
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