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Original Contributions Endothelium-Mediated and Direct Actions of

By Acetyicholine Rabbit, Aortic Baroreceptors and Paul A. Munch


Abstract Effects of exogenous acetylcholine on single-unit aortic baroreceptors were studied using a rabbit in vitro aortic arch/aortic nerve preparation. The arch was perfused with Krebs-Henseleit solution at constant pressure while simulta-neously recording arch diameter and baroreceptor discharge frequency. Administration of acetylcholine over a wide range of concentrations (10 ` to 10 ` mol/L) evoked multiple dose-dependent changes in baroreceptor activity. "Low " concentra-tions (<10-6 mol/L) consistently dilated arch and increased baroreceptor discharge (n=11). These responses were pre-vented by prerelaxing smooth muscle with sodium nitroprus-side (10 ` mol/L, n=6) and were augmented by precontracting smooth muscle with norepinephrine (0.5 x 10 ` mol/L, n=11). Thus, the baroreceptor responses were dependent quantita-tively on the level of preexisting vasoactive tone. The response

Year: 2016
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