by Sera From of Correlation


ABSTRACT-Sera from 23 hepatocellular carcinoma (HCC) pa-tients were studied for their effects on lymphocyte proliferation during polyclonal mitogen stimulation and one-way mixed lym-phocyte culture (MLC). The effect of 25 % HCC serum on tritiated thymidine uptake of cultures varied from slight augmentation to 95 % inhibition; however. no relationship was found between the potency of inhibition and serum alpha-fetoprotein (AFP) concen-tration. Purified AFP from the ascitic fluid of an HCC patient had no effect on MLC or cultures containing pokeweed mitogen; but at a concentration of 200 ILg/ml. AFP inhibited up to 30 % of the proliferative responses in cultures containing phytohemagglutinin or concanavalin A. Resultsstrongly suggest that the AFP in HCC sera is not inhibitory in itself.-JNCI 1981; 66:625-630. Much is already known about the structure and synthesis of human AFP during normal as well a

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