Neuroanatomical correlates of brainstem coma


The brainstem tegmentum, including the reticular for-mation, contains distinct nuclei, each of which has a set of chemical, physiological and anatomical features. Damage to the brainstem tegmentum is known to cause coma, the most radical disturbance of consciousness. However, it has remained unclear which nuclei within the tegmentum are crucial for the maintenance of con-sciousness in humans. Accordingly, we initiated a retro-spective study of MRIs obtained from 47 patients with brainstem stroke. The lesion boundaries were charted on patient MRIs and transferred onto a corresponding series of 4.7 T MRIs obtained from a control brainstem specimen that later was cut on a freezing microtome and analysed histologically. In addition, medical charts and available post-mortem materials were used t

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oaioai:CiteSeerX.psu: time updated on 4/12/2017

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