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HEMATOPOESIS Notch ligands Delta1 and Jagged1 transmit distinct signals to T-cell precursors

By Sophie M. Lehar, James Dooley, Andrew G. Farr and Michael J. Bevan

Abstract

Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Us-ing an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct sig-nals to T-cell progenitors. OP9 stromal cells expressing either Jagged1 or Delta1 inhibit the differentiation of DN1 thymo-cytes into the B-cell lineage, but only the Delta1-expressing stromal cells promote the proliferation and maturation of T-cell progenitors through the early double-negative (DN) stages of thymocyte devel-opment. Whereas the majority of bone marrow–derived stem cells do not re-spond to Jagged1 signals, T-cell progeni-tors respond to Jagged1 signals during a brief window of their development be-tween the DN1 and DN3 stages of thymic development. During these stages, Jagged1 signals can influence the differ-entiation of immature thymocytes along the natural killer (NK) and T-cell lin-eages. (Blood. 2005;105:1440-1447) © 2005 by The American Society of Hematolog

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.1007.8380
Provided by: CiteSeerX
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