Quantitative changes in myometrial activity in the guinea-pig during pregnancy

Abstract

Summary. Intrauterine pressure recordings were made in non-pregnant guinea-pigs, and in either the gravid horn of bilaterally pregnant, or the sterile horn of unilaterally pregnant animals. The results showed that, rather than a reduction of uterine activity during the luteal phase of the oestrous cycle, there was a significant increase compared with the level at oestrus. Activity during pregnancy was reduced compared with non-pregnant levels and this reduction was accomplished by a lowered frequency ofpressure cycles while their amplitude remained unchanged. The activity of the gravid horn was significantly less than that of the sterile horn during the mid-third of pregnancy. Both the sterile and gravid horns responded to oxytocin at all stages ofpregnancy. From these results, it is suggested that progesterone may not be a myometrial regulatory agent in the guinea-pig

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