Study Response to d’Annunzio, Russo,

Abstract

W e thank d’Annunzio, Russo, andLorini (1) for their interest in ourarticle (2) related to carbohy-drate-insulin variables in youth and later adult pre-diabetes and diabetes. As they noted, normal values of homeostasis model assessment of insulin resistance (HOMA-IR) are increased with sexual maturation. This is consistent with our previous findings in Bogalusa, Louisiana, with children. Svec et al. (3) reported ear-lier that there was a positive trend of post-glucose insulin response with increasing Tanner stages. The study cohort from our popula-tion emphasized the usefulness and the need to develop common cut-off values o

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