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Essential fatty acids profile and lipid peroxides in severe pre-eclampsia

By Thanaa Abou Shoukl, Mohammed Nagib Omar and Salah Taha Fayed


SUMMARY. There is increasing evidence that an imbalance between products of arachidonic acid metabolism (such as prostaglandins, prostacyclin and thromboxane A2) and lipid peroxidation products might have a role in the pathogenesis of pre-eclampsia. In order to study some of the changes taking place in pre-eclampsia, the plasma concentrations of essential fatty acids and lipid peroxidation products [measured as thiobarbituric-acid (TBA)-reactive substance] were evaluated in 25 patients with severe pre-eclampsia and 20 normal pregnant control subjects. Arachidonic acid concentration (median and range) was significantly higher in the pre-eclamptic group (14,1; 11·0-19·8 Jig/L) compared with the normal pregnant subjects (2'5; 2·0-4-4Jig/L). Plasma concentration of TBA-reactive substance was also significantly higher in the pre-eclamptic cases (14'8; 13·4-16,8 vs 11-4; 9·0- 12,8). These results suggest that arachidonic acid and lipid peroxidation products may playa role in the pathogenesis of pre-eclampsia. Additional key phrases: arachidonic acid, linoleic acid, linolenic aci

Year: 2016
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