Essential fatty acids profile and lipid peroxides in severe pre-eclampsia

Abstract

SUMMARY. There is increasing evidence that an imbalance between products of arachidonic acid metabolism (such as prostaglandins, prostacyclin and thromboxane A2) and lipid peroxidation products might have a role in the pathogenesis of pre-eclampsia. In order to study some of the changes taking place in pre-eclampsia, the plasma concentrations of essential fatty acids and lipid peroxidation products [measured as thiobarbituric-acid (TBA)-reactive substance] were evaluated in 25 patients with severe pre-eclampsia and 20 normal pregnant control subjects. Arachidonic acid concentration (median and range) was significantly higher in the pre-eclamptic group (14,1; 11·0-19·8 Jig/L) compared with the normal pregnant subjects (2'5; 2·0-4-4Jig/L). Plasma concentration of TBA-reactive substance was also significantly higher in the pre-eclamptic cases (14'8; 13·4-16,8 vs 11-4; 9·0- 12,8). These results suggest that arachidonic acid and lipid peroxidation products may playa role in the pathogenesis of pre-eclampsia. Additional key phrases: arachidonic acid, linoleic acid, linolenic aci

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