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SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

By Saravanan Rajendrasozhan, Se-Ran Yang, Vuokko L. Kinnula and Irfan Rahman

Abstract

Rationale: Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD+-dependent protein/histone deacetylase that regulates proinflammatory mediators by deacetylating histone and nonhistone proteins

Topics: B. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2292827
Provided by: PubMed Central
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