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Combination Echinocandin-Polyene Treatment of Murine Mucormycosis▿

By Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Yue Fu, John E. Edwards and Brad Spellberg


We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect

Topics: Experimental Therapeutics
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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