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Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase▿

By Christoph Ruckenstuhl, Andrea Poschenel, Reinhard Possert, Pravas Kumar Baral, Karl Gruber and Friederike Turnowsky

Abstract

Saccharomyces cerevisiae squalene epoxidase contains two highly conserved motifs, 1 and 2, of unknown function. Amino acid substitutions in both regions reduce enzyme activity and/or alter allylamine sensitivity. In the homology model, these motifs flank the flavin adenine dinucleotide cofactor and form part of the interface between cofactor and substrate binding domains

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2292544
Provided by: PubMed Central
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