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By Head Neck Pathol Mar and Pathol Annu Pt

Abstract

The present study is a retrospective review of patients with CXPA extracted from the National Cancer Institute's SEER database. Patients from 1986-2008 provided by 17 registries were identified using the November 2010 submission. Cases of CXPA were identified using the International Classification for Childhood Cancer site recode extended ICD-0-3 histology code 8941/3. Carcinoma ex pleomorphic adenoma (CXPA) is a rare and aggressive tumor that accounts for ~11 % of salivary gland malignancies (1). Tumors most commonly occur in the parotid gland but can also occur in submandibular glands, minor salivary glands, lacrimal gland and breast tissue (2). The tumor is comprised of a mixed histology of malignant tissue in the presence of benign pleomorphic adenoma which makes pathological diagnosis challenging. Prognosis is extremely variable and multifactorial, which explains the wide range of reported 5-year survival, 25-75 % (2, 3). CXPA is a heterogeneous class of tumors and treatment varies accordingly. Clinical management typically involves surgical resection with or without post-operative radiotherapy; however, the role and efficacy of radiotherapy is not well defined. (2) Given the rarity of the diagnosis, little data are available to guide therapeutic management and there are no randomized data on this entity. Single institution retrospective reviews have suggested that post-operative radiation can significantly improve local control rates (4). Overall Survival (OS) was improved with radiation only in those patients with negative LNs. The overall trend was for shorter OS in those who received adjuvant radiation (4). Here we investigate the patient and tumor characteristics as well as treatment modality in the outcome of patients with CXPA using th

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.1004.380
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