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IL-13 induces a bronchial epithelial phenotype that is profibrotic

By Nikita K Malavia, Justin D Mih, Christopher B Raub, Bao T Dinh and Steven C George
Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2292179
Provided by: PubMed Central
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    1. (2001). A: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med
    2. (1998). A: Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.
    3. (1999). Airway remodeling and repair.
    4. (2005). Airway remodeling in asthma. Curr Opin Pulm Med
    5. (2005). Airway smooth muscle: a modulator of airway remodeling in asthma.
    6. (2004). DE: Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc
    7. (2001). DE: The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma.
    8. (2008). Dorscheid DR: Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF.
    9. (2005). Elias JA: Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda)
    10. (1999). Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
    11. Epithelial barriers, compartmentation, and cancer.
    12. (2003). Epithelial cell modulation of airway fibrosis in asthma.
    13. (2001). Epithelium-fibroblast interactions in response to airway inflammation. Immunol Cell Biol
    14. (2002). Erle DJ: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med
    15. (2000). Fibrosis and airway remodelling. Clin Exp Allergy
    16. (2001). G: Airway remodeling in the pathogenesis of asthma. Curr Allergy Asthma Rep
    17. (2004). GL: Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol
    18. (2003). H: IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
    19. (2003). Holgate ST: Airway remodeling in asthma: new insights.
    20. (2003). Holgate ST: The airway epithelium: structural and functional properties in health and disease. Respirology
    21. (1999). Homer RJ: Airway remodeling in asthma.
    22. (2004). Homer RJ: Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clin Chest Med
    23. (2003). Howarth P: Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma.
    24. (1995). Is asthma a fibrotic disease? Chest
    25. (2005). JA: IL11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
    26. (2001). JA: Interleukin13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med
    27. (2007). JG: Basic mechanisms of development of airway structural changes in asthma. Eur Respir J
    28. (2001). JV: Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med
    29. (2001). Mechanical stress is communicated between different cell types to elicit matrix remodeling.
    30. (2003). Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.
    31. (1996). Nettesheim P: Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells.
    32. (2006). PP: Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells. Respir Res
    33. (2001). Remodeling in asthma and chronic obstructive lung disease.
    34. (2003). Rennard SI: Interferon-gamma reduces interleukin-4- and interleukin13-augmented transforming growth factor-beta2 production in human bronchial epithelial cells by targeting Smads. Chest
    35. (1987). RH: The effect of transforming growth factorbeta on cell proliferation and collagen formation by lung fibroblasts.
    36. (1998). RJ: Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro.
    37. (1999). RJ: Differences between cytokine release from bronchial epithelial cells of asthmatic patients and non-asthmatic subjects: effect of exposure to diesel exhaust particles. Int Arch Allergy Immunol
    38. (2006). SC: Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis.
    39. (2007). SC: Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells.
    40. (2007). SC: Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy.
    41. (2001). SC: Two-photon laser scanning microscopy of epithelial cell-modulated collagen density in engineered human lung tissue. Tissue Eng
    42. (2004). SE: Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
    43. (2002). ST: Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma.
    44. (1998). The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium. Clin Exp Allergy
    45. (2002). The relationship of reticular basement membrane thickness to airway wall remodeling in asthma.
    46. (2007). The role of epithelial injury and repair in the origins of asthma. Curr Opin Allergy Clin Immunol
    47. (2001). Tournier F: IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells.
    48. (2006). Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc
    49. (2002). Tromberg BJ: Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence.
    50. (2001). Tromberg BJ: Two-photon excitation laser scanning microscopy of human, porcine, and rabbit nasal septal cartilage. Tissue Eng
    51. (2001). Umetsu DT: Critical role for IL-13 in the development of allergen-induced airway hyperreactivity.
    52. (2000). WV: The molecular basis of lung morphogenesis. Mech Dev
    53. (2005). WW: Interpreting second-harmonic generation images of collagen I fibrils.

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