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Inferring MicroRNA Activities by Combining Gene Expression with MicroRNA Target Prediction

By Chao Cheng and Lei M. Li
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  31. (2007). NCBI GEO: mining tens of millions of expression profiles–database and tools update.
  32. (2005). Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs.
  33. (1993). Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C.
  34. (2007). Posttranslational regulation of the let-7 microRNA during neural cell specification.
  35. (2003). Prediction of mammalian microRNA targets.
  36. (2002). Prediction of plant microRNA targets.
  37. (2005). Regulation by let7 and lin-4 miRNAs results in target mRNA degradation.
  38. (2005). Silence from within: endogenous siRNAs and miRNAs.
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  44. (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
  45. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
  46. (2007). The Stanford Microarray Database: implementation of new analysis tools and open source release of software.
  47. (2004). Transcription and processing of human microRNA precursors.
  48. (2007). Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression.