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Evidence for Improved Cardiac Performance after Beta-Blockade in Patients with Coronary Artery Disease



The study was undertaken to investigate the acute haemodynamic effects of bunitrolol {0-2-hydroxy-'i-{tert.butylamino)-propoxy)-benzonitril-hydrochlo-ride), a cardioselectíve beta-blocker with partial agonist activity. Right and left heart catheterization was performed in eleven patients with documented coronary artery disease. After bunitrolol {10 mg i.V.), there was a statisti-cally significant decrease in left ventricular and aortic systolic pressures, left ventricular end-diastolic pressure, aortic diastolic and mean pressures, pressure-rate product and compliance index {¿\PlÍ\V). Left ventricular dpjdt, left ventricular dpjdt over isovolumic pressure, systemic resistance and heart rate tended to decrease, stroke volume and left ventricular stroke work index tended to increase, without statistical significance. Cardiac index.showed individual variations, the mean values for the group being unchanged. Correlation of left ventricular ettd-diastolic pressure and left ventricular stroke work index showed a shift toward Improved veiUricular function curve in most cases, deterioration in no instance. Supine exercise was performed i

Year: 2016
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