Testosterone and Atherosclerosis Progression in Men

Abstract

There is a widespread perception thatthe gender differences in the preva-lence of coronary artery disease (CAD) are due to higher testosterone con-centrations in men and that testosterone supplementation in men would adversely affect the plasma lipoprotein profile, therefore increasing the risk of atheroscle-rotic heart disease. The case reports of cardiovascular accidents among athletes who had abused androgenic steroids have strengthened this notion; however, there are no data substantiating a cause-and-effect relationship between androgens and cardiovascular disease. The manu-script by Fukui et al. (1) in this issue of Diabetes Care adds to a growing body o

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