Rapid Clearanceof Iodine-131 MIBG from the Heart and Liver of Patients with AdrenergicDysfunction

Abstract

isa radioiodinatedanalogofguanethidine,anadrenergic blocking agent (1). The affinity of [‘31I]MIBGfor the adrenal medullae has proven useful in the scintigraphic localization of pheochromocytoma (2,3) and the as sessment of adrenal medullary hyperplasia (4). It has been suggested that radioiodinated MIBG may be taken up and stored in adrenergic neurons by the same mech anism as that for norepinephrine (NE) (5). It has also been shown that the efflu.x ofNE from the isolated rabbit heart differs between neuronal and extraneuronal compartments (6); the efflux ofNE is more rapid from the extraneuronal compartments than from the adren ergic neuronal compartments. The efflux of guanethidine (an analog of MIBG) from the extravesicular cor

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