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Quantitative and qualitative T-cell measurements ex vivo allow to distinguish between spontaneous and vaccine-induced antigen-specific T-cell responses, and a combination thereof. The majority of currently applied tumor vaccines induce T-cell responses in only a fraction of patients, suggesting that patient and disease related factors are co-responsible for T-cell activation. In contrast, the use of CpG oligodeoxynucleotide 7909 as immune adjuvant leads to reproducible ex vivo detectable T-cell responses in all vaccinated patients, enabling for the first time to study immune responses that are dominantly elicited by the vaccine. Spontaneous tumor antigen specific T-cell responses The HLA-A2/Melan-A(MART-1) antigenic system constitutes a well-defined model for studies of CD8+ T-cell responses in humans (1, 2, 3). For all studies, we use a standardized approac

Year: 2016
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