RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects


OBJECTIVE — To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor (CCR5 gene) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects. RESEARCH DESIGN AND METHODS — A total 616 Japanese subjects with type 2 diabetes were recruited. Polymorphisms of 28 C/G and 403 G/A in the RANTES gene promoter region, and of 59029 G/A in the CCR5 gene promoter region were detected by PCR-RFLP (restriction fragment length polymorphism). The association of these genotypes with nephropathy was analyzed. RESULTS — While the RANTES –403 genotype showed no association with nephropathy, the frequency of the –28G allele was significantly higher in the DN2 group (urinary albuminuria-to-creatinine ratio [ACR]300 mg/g creatinine, serum creatinine2.0 mg/dl) than in the DN0 (ACR 30 mg/g creatinine) and DN1 (ACR 30 mg/g creatinine and 300 mg/g creatinine) groups. The frequency of a RANTES –28G-positive genotype (C/G or G/G) was higher in the DN2 group than in the DN0 and DN1 groups (34 % vs. 25 and 20%, P 0.0268, 2 4.905), and the frequency of a CCR5 59029 A-positive genotype (G/A or A/A) was higher in the DN1 an

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