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Oxygen Consumption in Aortic Tissue from Rabbits with Diet-Induced Atherosclerosis

By Tom Bjfirnheden and Gsran Bondjers


The inner parts of the arterial wall depend upon diffusion for nutrition and oxygerv atlon. During the atherosclerotic process, Increased intimal thickness leads to im-paired diffusion, and at the same time the oxygen requirements Increase. On this basis it has been suggested that the balance between the supply and demand of oxygen In the arterial wall may be Important for the fate of the Initiated lesion. In the first part of the present study, the oxygen consumption was measured during perfu-slon In aortic intima-medla segments from cholesterol-fed rabbits. The results Indicat-ed that the oxygen consumption per DNA Increased with Increasing degree of athero-sclerotic Involvement up to a certain level. For more diseased aortas, however, the oxygen consumption decreased again. In the second part of the study, the oxygen consumption was measured In foam cell and smooth muscle cell fractions isolated from rabbit aortic Intlma-media. These measurements indicated that the oxygen con-sumption of Isolated foam cells was three times higher than that of isolated smooth muscle cells. It Is proposed In the study that the increased oxygen consumption of the less diseased aortas reflected an Increased proportion of foam cells In the arteria

Year: 2016
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