IN THE paper which first described thepressor effect of kidney extracts, Tiger-stedt and Bergman1 reported that, on repeated intravenous injection of the substance which they called renin, the response in the rabbit became less pronounced. This observation was confirmed by various investigators, and the effect was denoted as renin tachyphylaxis. Goldblatt et al.,2 in a careful analysis of this phenomenon, demonstrated that the response to repeated injections of the same dose of renin is diminished only if the intervals be-tween the doses are so short that the blood pressure cannot return to its initial value. Hence, the authors concluded that residual constriction of the arterioles following the first injection of renin is a factor at least partly responsible for the phenomenon of tachyphylaxis. This assumption is in agree-ment with the observation that the animal with a diminished response to renin showed also a reduced sensitivity to angiotensin (Goldblatt,2 Page et al.3). On the other hand, all authors working with angiotensin stated that, in contrast to renin, this polypeptide does not exhibit tachyphylaxis. However, we have already shown4 that after the adminis-tration of high doses of synthetic angiotensin, the reaction to subsequent smaller doses is diminished, i.e., a degree of tachyphylaxis develops, even when the blood pressure is al-lowed to return to normal between the single injections. Therefore, we reinvestigated the problem of renin tachyphylaxis: (a) to deter-mine the exact dose-response relationship for pure synthetic angiotensin and to compare its characteristics with that of renin; (b) to de-fine the conditions under which angiotensi

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