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Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice

By Marcus A. Mall, Jack R. Harkema, Joanna B. Trojanek, Diana Treis, Alessandra Livraghi, Susanne Schubert, Zhe Zhou, Silvia M. Kreda, Stephen L. Tilley, Elizabeth J. Hudson, Wanda K. O'Neal and Richard C. Boucher


Rationale: Chronic obstructive pulmonary disease is a leading cause of death worldwide, but its pathogenesis is not well understood. Previous studies have shown that airway surface dehydration in β-epithelial Na+ channel (βENaC)–overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors

Topics: C. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
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Provided by: PubMed Central
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