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Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412

By C M Dayan and D C Wraith

Abstract

Current immunology research is generating many new approaches to immunotherapy. However, the recent disaster surrounding the testing of TGN1412, has unsettled regulators and the pharmaceutical industry regarding new immunotherapies and highlighted the complexities of conducting clinical trials with agents that target the immune system. Here we discuss the critical role for immunologists in ensuring that the development of new immunotherapies continues

Topics: Review Article
Publisher: Blackwell Science Inc
OAI identifier: oai:pubmedcentral.nih.gov:2276942
Provided by: PubMed Central
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