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Intracellular machinery for the transport of AMPA receptors

By J A Esteban

Abstract

AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity

Topics: Reviews
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2268045
Provided by: PubMed Central
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