Skip to main content
Article thumbnail
Location of Repository

Functional evolution of the vitamin D and pregnane X receptors

By Erica J Reschly, Afonso Celso Dias Bainy, Jaco Joaquim Mattos, Lee R Hagey, Nathan Bahary, Sripal R Mada, Junhai Ou, Raman Venkataramanan and Matthew D Krasowski
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2263054
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2000). a chicken xenobioticsensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
    2. (2003). A: New insights into the mechanisms of vitamin D action.
    3. (2007). Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation.
    4. (2003). AF: Physicochemical and physiological properties of 5α-cyprinol sulfate, the toxic bile salt of cyprinid fish.
    5. (1998). an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes & Development
    6. (2002). Benzoate X receptors α and β are pharmacologically distinct and do not function as xenobiotic receptors.
    7. (1998). Berkenstram A: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
    8. (2001). Binding of ligands and activation of transcription by nuclear receptors.
    9. (1987). BW: Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science
    10. (2001). CD: Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos
    11. (1992). CO: Expression of cytochrome P450 3A in amphibian, rat, and human kidney. Archives of Biochemistry and Biophysics
    12. (1999). Collodi P: Preparation of primary cell cultures from lamprey.
    13. (2001). D: Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.
    14. (2003). Differential modulation of cytochrome P-450 1A and P-glycoprotein expression by aryl hydrocarbon receptor agonists and thyroid hormone in Xenopus laevis liver and intestine. Aquatic Toxicology
    15. (1993). DR: Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Archives of Biochemistry and Biophysics
    16. (1992). DW: Culture of cells from zebrafish (Brachydanio rerio) embryo and adult tissues. Cell Biology and Toxicology
    17. (2001). E: Transcriptional control of intestinal cytochrome P-4503A by 1a,25-dihydroxy vitamin D3. Molecular Pharmacology
    18. (2005). EG: Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts. Molecular Endocrinology
    19. (2005). EG: Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nuclear Receptor
    20. (2003). Evolution and function of vitamin D. Recent Results in Cancer Research
    21. (2001). Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions.
    22. (2001). Forman BM: The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.
    23. (2001). Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Science
    24. (1987). Grafström AK: Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.
    25. (1998). Gronemeyer H: The nuclear receptor ligand-binding domain: structure and function. Current Opinion in Cell Biology
    26. (2005). Haussler MR: Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.
    27. (1997). HF: Cloning and origin of the two forms of chicken vitamin D receptor. Archives of Biochemistry and Biophysics
    28. (2004). HF: Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide. Biochemistry
    29. (2007). HF: New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDRbound conformations.
    30. (1971). Identification and biosynthesis of steroid hormones in the gonads of Ciona intestinalis. Experientia
    31. (2000). Identification of cDNAs encoding two subtypes of vitamin D receptor in flounder, Paralichthys olivaceus.
    32. (1999). Induction of cytochrome P4501A1. Annual Review of Pharmacology and Toxicology
    33. (2001). Induction of cytochromes P450. Current Drug Metabolism
    34. (2007). JL: The farnesoid X receptor, FXRα/NR1H4, acquired ligand specificity for bile salts late in vertebrate evolution.
    35. (1998). JM: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell
    36. (2002). JT: Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Molecular Endocrinology
    37. (2000). JT: The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Molecular Endocrinology
    38. (1995). Korzekwa KR: Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. Biochemical Pharmacology
    39. (2004). Laudet V: Principles for modulation of the nuclear receptor superfamily. Nature Reviews Drug Discovery
    40. (1991). LJ: Coordinate regulation of fibrinogen subunit messenger RNA levels by glucocorticoids in primary cultures of Xenopus liver parenchymal cells. Molecular Endocrinology
    41. (2002). LS: CYP3A4 induction by drugs: correlation between a pregnane X receptor gene assay and CYP3A4 expression in human hepatocytes. Drug Metabolism and Disposition
    42. (2002). Mangelsdorf DJ: Vitamin D receptor as an intestinal bile acid sensor. Science
    43. (2003). Marchalonis JJ: Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology
    44. (1997). MB: Cloning and characterization of the vitamin D receptor from Xenopus laevis. Endocrinology
    45. (2006). MD: Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Current Drug Metabolism
    46. (2000). Molecular cloning and functional characterization of a novel nuclear receptor similar to an embryonic benzoate receptor BXR. Biochemical and Biophysical Research Communications
    47. (2005). Noncalcemic actions of vitamin D receptor ligands. Endocrine Reviews
    48. (2002). Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic distribution. Molecular Pharmacology
    49. (2001). Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.
    50. (1975). On the sterols of some ascidians.
    51. (1998). Ong ES, Evans RM: SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
    52. (2003). Ramamurthy L: The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Research
    53. (2003). RB: Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clin Pharmacol Ther
    54. (2004). RC: Comparative genomics. Annual Review of Genomics and Human Genetics
    55. (2002). Regulation of CYP3A gene transcription by the pregnane X receptor. Annual Review of Pharmacology and Toxicology
    56. (2006). Reschly EJ, Krasowski MD: Functional evolution of the pregnane X receptor.
    57. (2000). RW: Expression pattern of BXR suggests a role for benzoate ligand-mediated signalling in hatching gland function.
    58. (2003). Satoh N: A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFkB. Development Genes and Evolution
    59. (1999). SC: The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab Dispos
    60. (2000). Skaletsky H: Primer3 on the WWW for general users and for biologist programmers. Methods in Molecular Biology
    61. (2004). Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1a,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis.
    62. (2000). The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Molecular Cell
    63. (2007). The sea lamprey (Petromyzon marinus) has a receptor for androstenedione. Biology of Reproduction
    64. (1998). Tillitt DE: Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
    65. (1969). Tökés L: Comparative studies of bile salts: bile salts of the lamprey Petromyzon marinus L. Biochemical Journal
    66. (2000). TS: Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma.
    67. (2006). Tunicates and not cephalochordates are the closest living relatives of vertebrates. Nature
    68. (2004). UA: The evolution of drugactivated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor
    69. (2005). WH: Aryl hydrocarbon receptors in the frog Xenopus laevis: two AhR1 paralogs exhibit low affinity for 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). Toxicological Sciences
    70. (2002). Willson TM: Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.