(2002). AJ: Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.
(2000). AJ: Surfing the p53 network. Nature
(1998). Allatom empirical potential for molecular modeling and dynamics studies of proteins.
(2005). Attempts to delineate the relative contributions of changes in hydrophobicity and packing to changes in stability of ribonuclease S mutants. Biochemistry
(1993). Blundell TL: Comparative protein modelling by satisfaction of spatial restraints.
(1999). BW: Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability.
(2001). BW: Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme. Protein Sci
(1997). Caput D: Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell
(2005). Characterization of the denaturation of human alpha-lactalbumin in urea by molecular dynamics simulations. Proteins
(2006). CN: Hydrogen bonding increases packing density in the protein interior. Proteins
(2000). Collective protein dynamics in relation to function. Curr Opin Struct Biol
(2006). Comparison of the human and worm p53 structures suggests a way for enhancing stability. Biochemistry
(1992). Conjugate Peak Refinement: an algorithm for finding reaction paths and accurate transition states in systems with many degrees of freedom.
(2002). DR: Large and Fast Relaxations inside a protein: Calculation and Measurement of Reorganisation Energies in Alcohol Dehydrogenase.
(2006). Effect of Zn2+ ions on DNA recognition and stability of the p53 DNA-Binding Domain. Biochemistry
(1999). Ellington AD: In vitro evolution of thermostable p53 variants. Protein Sci
(1998). F: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, deathinducing, and dominant-negative activities. Mol Cell
(2002). Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain. Nucleic Acids Res
(1996). Fersht A: Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities. Biochemistry
(2002). Fersht AR: A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci
(2004). Fersht AR: Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.
(2006). Fersht AR: Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.
(2006). Fersht AR: Effects of oncogenic mutations and DNA response elements on the bindingBMC Bioinformatics 2008, 9(Suppl 1):S17 http://www.biomedcentral.com/1471-2105/9/S1/S17
(2000). Fersht AR: Mechanism of rescue of common p53 cancer mutations by secondsite suppressor mutations.
(2000). Fersht AR: Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy. Oncogene
(2007). Fersht AR: Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci USA
(1998). Fersht AR: Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.
(2006). Fersht AR: Solution structure of p53 core domain: structural basis for its instability. Proc Natl Acad Sci USA
(2006). Fersht AR: Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.
(2004). Fersht AR: Structural distortion of p53 by the mutation R249S and its rescue by designed peptide: implications for "mutant conformation".
(2007). Fersht AR: Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene
(2005). Fersht AR: Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations.
(1984). Haak JR: Molecular dynamics with coupling to an external bath.
(2001). High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
(1993). HJ: Essential dynamics of proteins. Proteins